Molecular Basis of Luminal Ca2+ Gating of the Cardiac Ryanodine Receptor
نویسندگان
چکیده
منابع مشابه
Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca2+
Introduction Cardiac myocyte contraction is driven by the coordinated release of Ca from the sarcoplasmic reticulum (SR). This release of Ca occurs through the cardiac RyR2. Physiologically, Ca release occurs in response to an influx of Ca through L-type Ca channels, via a mechanism termed CICR. This transient increase in cytosolic Ca activates the RyR2 channel as a result of Ca binding to the ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2009
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2008.12.2984